Mark J Millan Selected Research

S 32504

12/2006	Antiparkinsonian effects of the novel D3/D2 dopamine receptor agonist, S32504, in MPTP-lesioned marmosets: Mediation by D2, not D3, dopamine receptors.
11/2004	Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells.
6/2004	S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole.
6/2004	S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole.

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Mark J Millan Research Topics

Disease

18	Parkinson Disease (Parkinson's Disease) 06/2022 - 11/2002
16	Schizophrenia (Dementia Praecox) 12/2022 - 04/2005
10	Dyskinesias (Dyskinesia) 11/2020 - 06/2004
8	Cognitive Dysfunction 05/2020 - 05/2008
5	Alzheimer Disease (Alzheimer's Disease) 11/2022 - 09/2017
5	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2020 - 11/2016
5	Mental Disorders (Mental Disorder) 01/2020 - 02/2008
5	Substance-Related Disorders (Drug Abuse) 01/2018 - 03/2009
5	AIDS-Related Complex (ARC) 11/2012 - 04/2004
3	Psychotic Disorders (Schizoaffective Disorder) 12/2022 - 01/2016
3	Anxiety Disorders (Anxiety Disorder) 01/2022 - 06/2003
3	Parkinsonian Disorders (Parkinsonism) 01/2020 - 11/2006
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 09/2014
3	Thymoma (Thymic Carcinoma) 01/2020 - 03/2012
3	Neurobehavioral Manifestations 01/2014 - 04/2005
2	Brain Diseases (Brain Disorder) 01/2021 - 05/2020
2	Tremor (Tremors) 11/2020 - 01/2020
2	Neuroinflammatory Diseases 09/2017 - 09/2014
2	Nervous System Diseases (Neurological Disorders) 11/2016 - 05/2015
2	Memory Disorders (Memory Loss) 12/2014 - 05/2012
2	Hypothermia 11/2011 - 02/2008
2	Mood Disorders (Mood Disorder) 09/2011 - 10/2009
2	Gambling (Pathological Gambling) 02/2011 - 12/2009
2	Hypokinesia (Bradykinesia) 02/2010 - 06/2004
2	Anhedonia 09/2008 - 06/2004
2	Central Nervous System Diseases (CNS Diseases) 09/2008 - 12/2005
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2022
1	Tauopathies 11/2021
1	Hypertensive Crisis 01/2021
1	Dystonia (Limb Dystonia) 11/2020
1	Autism Spectrum Disorder 05/2020
1	Insulin Resistance 01/2020

Drug/Important Bio-Agent (IBA)

11	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 11/2006
11	Levodopa (L Dopa)FDA LinkGeneric 01/2020 - 06/2004
8	Serotonin (5 Hydroxytryptamine)IBA 01/2022 - 11/2002
6	Messenger RNA (mRNA)IBA 11/2012 - 04/2004
5	Proteins (Proteins, Gene)FDA Link 11/2021 - 09/2014
5	LigandsIBA 10/2020 - 02/2010
5	Pramipexole (Mirapex)FDA LinkGeneric 01/2020 - 11/2004
5	MicroRNAs (MicroRNA)IBA 01/2019 - 02/2011
5	Antidepressive Agents (Antidepressants)IBA 05/2015 - 04/2004
5	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/2012 - 04/2004
5	N- (4- (2- (8- cyano- 1,3a,4,9b- tetrahydro(1)benzopyrano(3,4- c)pyrrol- 2(3H)- yl)ethyl)phenyl)acetamideIBA 09/2010 - 02/2008
4	Antipsychotic Agents (Antipsychotics)IBA 12/2022 - 04/2005
4	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022 - 04/2004
4	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2020 - 04/2005
4	Corticotropin-Releasing HormoneIBA 01/2018 - 02/2008
4	Dopamine D3 ReceptorsIBA 09/2010 - 04/2005
4	S 32504IBA 12/2006 - 06/2004
3	agomelatine (S20098)IBA 01/2022 - 10/2009
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022 - 06/2003
3	Oxidopamine (6 Hydroxydopamine)IBA 01/2019 - 02/2010
3	Cholinergic Agents (Cholinergics)IBA 01/2017 - 03/2008
3	Cocaine (Cocaine HCl)IBA 12/2014 - 03/2012
3	Serotonin and Noradrenaline Reuptake InhibitorsIBA 06/2012 - 04/2004
3	Venlafaxine Hydrochloride (Effexor)FDA LinkGeneric 06/2012 - 04/2004
3	Antiparkinson Agents (Antiparkinsonian Agents)IBA 02/2011 - 11/2002
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 09/2010 - 11/2006
2	BenzodiazepinesIBA 01/2022 - 06/2003
2	NeuropeptidesIBA 01/2022 - 11/2013
2	Dopamine Agonists (Dopamine Agonist)IBA 11/2020 - 02/2007
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 05/2020 - 04/2005
2	Sirolimus (Rapamycin)FDA Link 01/2020 - 10/2012
2	ropinirole (Requip)FDA LinkGeneric 01/2018 - 11/2010
2	AMPA Receptors (AMPA Receptor)IBA 10/2015 - 11/2012
2	Biomarkers (Surrogate Marker)IBA 05/2015 - 04/2015
2	Therapeutic UsesIBA 05/2015 - 05/2012
2	TachykininsIBA 01/2014 - 12/2005
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2013 - 03/2012
2	Dizocilpine Maleate (Dizocilpine)IBA 02/2013 - 11/2012
2	N-Methylaspartate (NMDA)IBA 11/2012 - 04/2005
2	Adrenergic Receptors (Adrenergic Receptor)IBA 06/2012 - 11/2006
2	Piribedil (Trivastal)IBA 11/2010 - 11/2006
2	Histamine (Histamine Dihydrochloride)FDA Link 05/2008 - 11/2002
2	1- (1- dimethylaminomethyl- 5- methoxybenzocyclobutan- 1- yl)cyclohexanolIBA 07/2004 - 04/2004
2	CyclohexanolsIBA 07/2004 - 04/2004
1	5-HT1A Serotonin ReceptorIBA 12/2022
1	Apolipoprotein E3IBA 11/2022
1	Apolipoprotein E4IBA 11/2022
1	Protein Isoforms (Isoforms)IBA 11/2022
1	CholesterolIBA 11/2022
1	naxagolideIBA 06/2022
1	MelatoninIBA 01/2022
1	mesotocin receptorIBA 01/2022
1	5-HT2C Serotonin ReceptorIBA 01/2022
1	Serine (L-Serine)FDA Link 01/2021
1	TyramineIBA 01/2021
1	Glutamic Acid (Glutamate)FDA Link 01/2021
1	Apomorphine FDA Link 11/2020
1	QuinpiroleIBA 11/2020
1	Memantine (Namenda)FDA Link 10/2020
1	Cholinesterases (Cholinesterase)IBA 10/2020
1	Regulatory-Associated Protein of mTORIBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Hormones (Hormone)IBA 01/2020
1	KetonesIBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020

Therapy/Procedure

8	Therapeutics 01/2022 - 05/2008
3	Drug Therapy (Chemotherapy) 07/2016 - 05/2015